Methyl tert-butyl ether (MTBE), a key organic compound that exhibits a slight solubility to water and a high solubility to ethanol and ether, plays an important role in the manufacture of pharmaceuticals and their active substances, especially as a base material for the synthesis of pharmaceutical intermediates such as Azisartan and rosuvastatin calcium.

A common challenge in the synthesis of MTBE is the residual salt impurities in the solvent. Traditionally, this problem has been solved by introducing pure water into a stirred kettle, then mixing it, then going through a process of precipitation and static delamination, and finally relying on manual means to achieve separation. However, this process needs to be repeated until the salt content meets the strict requirements of the production process. This method not only takes a long time, leads to the discontinuity of the production process, but also has low efficiency and high labor intensity, so it has become one of the focuses of technological transformation of process equipment in the field of pharmaceutical synthesis.

Extraction technology, as an important means to purify and purify compounds in the field of biomedicine engineering, has wide application value. Among them, centrifugal solvent extraction technology has shown significant advantages in many fields such as raw materials, botanical drugs and traditional Chinese medicine, antibiotics, organic acids and so on. In addition, the technology is also widely used in the production of food additives, functional foods, daily chemicals, bio-derived pesticides and veterinary drugs. With the rapid development in the fields of life science, bioengineering, synthetic pharmacy, environmental science and food engineering, more and more objects need to be extracted, and the efficient separation of components in complex substrates has become a key problem to be solved urgently. Under this background, centrifugal solvent extraction technology is expected to gain greater development space and application potential.