Salt/crystal research is of great significance in the development of apis, which can improve the biopharmaceutical properties of apis and the technical feasibility of preparation production.

The purpose of salt type research is to determine the most suitable salt type, so as to improve the performance of the API and the feasibility of the preparation process. Different salt types belong to different new chemical entities (NCE), and selecting suitable salt types can improve the solubility, stability and bioavailability of drugs. In the preclinical stage, it is very important to identify the salt type, as this will have a major impact on the development and registration of drugs.

The purpose of crystal type research is to find the most thermodynamically stable crystal type and develop it further. Different crystal forms have different physical and chemical properties, which have important effects on the solubility, stability, preparability and bioavailability of drugs. Through crystal type screening, the most stable crystal type can be found to improve the quality and stability of drugs.

The combined extraction centrifugal extractor has an important application in the study of salt type/crystal type. The equipment can achieve efficient separation and purification of target components by adjusting parameters such as centrifugal force and temperature. In the study of salt type, the combined extraction centrifugal extractor can be used to remove impurities and improve the purity and activity of salt type. In the crystal research, the combined extraction centrifugal extractor can realize the separation and purification of the crystal, and help find the most stable crystal.

The combined extraction centrifugal extractor also enables in-situ monitoring of raw materials during salt/crystal studies. Through online research on the formation and transformation process of salt/crystal forms, we can understand their dynamic behavior and influencing factors. This helps to optimize the research process and accelerate the screening and development of salt/crystal forms.

The study of salt type/crystal type plays an important role in the development of apis. By selecting the suitable salt type and the most stable crystal type, the performance of the API and the feasibility of the preparation process can be improved. As a kind of high efficiency separation equipment, the combined extraction centrifugal extractor has important application value in the research of salt and crystal. Through its application, it can achieve efficient separation and purification of salt and crystal forms, help optimize the research process, and accelerate the screening and development of salt/crystal forms.